Kitten AK, Kamath M, Ryan L, et al
Endocrinology 148 (10), 47044710 (2007)
Symptoms in these cases may include growth retardation, intellectual disability, or acute metabolic disorders caused by metabolic stress, mainly manifested as infections, but also with systemic complications, such as epilepsy, ketoacidosis, recurrent vomiting, leukopenia, or cardiac muscle disease [11]
In preclinical research, doses from 6 g/kg to 20 mg/kg caused no acute organ toxicity, and thorough mutagenicity, genotoxicity, and teratogenicity assays returned negative results
Do not assume the medication is worthlesssome potency may remainbut clinical effectiveness could be compromised
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis