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This gastrointestinal symptom results from semaglutide's mechanism of slowing gastric emptying, which can cause increased stomach pressure and gas accumulation

It also helps people feel fuller and delays gastric emptying, meaning they can consume fewer calories, as Medical News Today notes

2019 Jul;120(7):11921-11930

It consists of a 31-amino acid peptide backbone with several structural modifications designed to extend its biological half-life, including a C-18 fatty acid chain attached via a linker to a lysine residue

Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly