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Glucagon-like peptide-1 receptor regulates receptor of advanced glycation end products in high glucose-treated rat mesangial cells

The article says naltrexone blocks opioid receptors in the hypothalamus, removing inhibition of pro-opiomelanocortin neurons that regulate satiety, while bupropion is a norepinephrine-dopamine reuptake inhibitor that increases alertness and reduces appetite by raising dopamine and norepinephrine in the brain's appetite-control centres

Diabetes Care 2005;28:1936-1940

All GLP-1 receptor agonists carry a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2

PMID: 7535143

Drug Interactions May impact absorption of orally administered medications