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Its a two-way street in IBD, with the gut microbiome changes potentially causing high homocysteine, but then high homocysteine will increase the inflammation in the gut.[ref] Gastrointestinal production of homocysteine: Gut microbes that produce folate: The amount of folate produced by the gut microbiome is on a similar scale to what we get from food, so it is a significant source of folate for most people

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doi:10.1016/j.biortech.2008.06.012 Liang G, Mo Y, Du G (2010) Optimization of sodium dedecyl sulfate (SDS) addition coupled with adenosine triphosphate (ATP) regeneration for glutathione overproduction in high density cultivation of Candida utilis

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