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A 43-amino acid synthetic peptide modeled after thymosin beta-4.- Reported to regulate actin dynamics via its LKKTETQ sequence, thereby influencing cellular migration and motility.- May also elevate microRNA-146a, which suppresses inflammatory pathways involving IRAK1 and TRAF6.- Preclinical studies point toward roles in wound contraction, tissue vascularization, and cardiac resilience under stress

In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision

Retrieved from NCBI, February 20, 2026