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ET on Nov 22, 2025

Fish species rich in omega-3 fatty acidssuch as salmon, mackerel, and sardinesprovide dual benefits: they stimulate GLP-1 release while reducing systemic inflammation linked to obesity and metabolic dysfunction

In a Phase 2a substudy published in Nature Medicine, retatrutide at the 12mg dose reduced liver fat by an average of 82.4% from baseline at 24 weeks

29 These results suggests that the reported negative retinopathy outcomes observed in some studies may not be specific to the GLP-1/GIP agonists, but rather scenarios where their use resulted in larger drops in A1c

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