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(c) By contrast, in an open observational study from the Czech Republic, vitamin C (0.5 gm/day) plus vitamin E (100 mg/day) for 12 months resulted in substantial pain reduction, to the point of abolition in 44% of 70 patients with mainly alcoholic disease

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Paraxanthine metabolism in humans: determination of metabolic partial clearances and effects of allopurinol and cimetidine