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Once a peptide is in solution, freezing causes ice crystals to form, and those crystals physically shear the peptide chain apart a form of structural damage thats irreversible

Possible major anthropometric, environmental, genetic, and epigenetic factors are listed

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It works especially well for those with a body mass index (BMI) of 30 or more, or for people with a BMI of 27 or higher who also have other linked medical issues, including high blood pressure, high cholesterol , or type 2 diabetes