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Renal Impairment Initiation of XIGDUO XR is not recommended in patients with an eGFR below 45 mL/min/1.73 m and is contraindicated in patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m) or end-stage renal disease [see DOSAGE AND ADMINISTRATION , CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS ]

Food and Drug Administration (FDA) in 2022 under the brand name Mounjaro, Tirzepatide represents a new class of diabetes treatment that works differently from traditional drugs

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1 2 Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (3rd ed.)

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