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Female reproductive aging and oxidative stress: mesenchymal stem cell conditioned medium as a promising antioxidant

Parathyroid hormone (PTH) upregulates CYP27B1 and downregulates CYP24A1 to promote active Vitamin D synthesis, whereas fibroblast growth factor 23 (FGF23) exerts opposing effects [97, 98].Additionally, serum phosphate, calcium levels, and 1,25(OH)D itself participate in feedback regulation, creating a dynamic and complex endocrine network [94]

The GLP-1RA needs to cross the Blood-Brain Barrier (BBB) to act on the brain and exert neuroprotective effects (12, 22)

We address GLP-1 side effects actively rather than as an inevitable cost of treatment