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Although glutamine is required as an alternative fuel for the tricarboxylic acid cycle (TCA) to produce ATP, it also contributes to a wide range of pathways in cells, producing amino acids, nucleotides and fatty acids as well as playing an important role in reactive oxygen species (ROS) homeostasis, mTOR activation and the hexosamine biosynthesis pathway (Figure 1)

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By understanding the different types of lip pigmentation disorders, we can better determine the most appropriate treatment options, whether it be hyperpigmented lips treatment , lip lightening treatment , or other therapies

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