Knowing that Mounjaro and Zepbound both contain tirzepatide, while carrying different approved uses, helps explain why one might be covered and another might not, even though the molecule is identical across both
Keep in mind that humans are not rats
46 The mainstream view holds that the canonical GLP-1 receptor is not expressed in the human liver, and any hepatic effects are likely mediated through extrahepatic mechanisms rather than direct action
This suggests a long-term protective strategy beyond immediate inflammatory suppression
55 However, other roles of nonredox function on this phenotype were not specifically explored
Bertalot G, Montresor G, Tampieri M, Spasiano A, Pedroni M, Milanesi B, et al