Theyre typically prescribed for: Adults with type 2 diabetes
Their activation is triggered by the recognition of pathogen-associated molecular patterns (PAMPs), such as bacterial flagellin, and damage-associated molecular patterns (DAMPs), including uric acid crystals
Rahman, I., et al., Characterisation of gamma-glutamylcysteine synthetase-heavy subunit promoter: a critical role for AP-1
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The most plausible confounding factor is malaise, which is a common side effect of the GLP-1R agonists used (Kanoski et al., 2012)
Common gastrointestinal side effects (nausea, vomiting, constipation) may be managed through smaller meals, adequate hydration, and monitoring individual food tolerance