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Its available in pill and nasal spray (Gimoti) forms, with the nasal spray often having fewer side effects
Contact the clinician for severe pain, inability to open the mouth, major bite change, progressive chewing weakness, or significant smile asymmetry
As a triple incretin receptor agonist, it: Activates GLP-1 receptors , reducing appetite, slowing gastric emptying, and improving insulin secretion Activates GIP receptors , enhancing insulin response and potentially supporting fat metabolism Activates glucagon receptors , increasing energy expenditure and hepatic glucose output Whilst glucagon receptor activation increases hepatic glucose output, the net glycaemic effect of retatrutide is mitigated by the concurrent GLP-1 and GIP activity, resulting in overall improvements in glycaemic control in trial participants
Physical examination of the thyroid gland should be performed as part of the baseline assessment
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