Dosing interval : 46 hours apart to optimize absorption peaks
they offer a boost in energy, an uplift in mood, sharper cognitive functions, and even support in weight management efforts
Packer recently proposed an intriguing hypothesis that DPP-4 inhibitors potentiate some endogenous peptides, such as stromal cell-derived factor-1, in addition to activation of GLP-1, and that unfavorable effects of those peptides on CV parameters (e.g., inflammation, fibrosis, plaque growth, and sympathetic activation) could prevail against the CV protective effects of GLP-1, possibly leading to worsened CV complications and HF [36, 37]
Long-term controlled safety data are absent
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Rahman, L., et al