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Moreover, Laboratory 2 observed that, in general, the concentration related changes induced by the benchmark chemicals ranged from increased cell degeneration, separation/detachment, multifocal thinning (e.g., Crystalline silica, Amorphous silica, and Doxorubicin) and with more severe injury locally extensive cell death/necrosis (e.g., PHMG and Akemi)

Steroids (increased protein catabolism)

The strongest skin evidence: Watanabe et al

New blood vessel growth serves healing purposes, but uncontrolled angiogenesis has implications for conditions involving abnormal vascular proliferation

To inhibit TGR activity, NTS were treated with compounds (30 M) or auranofin (5 M) for 2 h