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Abbreviations BMD: Bone mineral density CRP: C-reactive protein DKK1: Dickkopf-1 DXA: Dual-energy X-ray absorptiometry FGF-23: Fibroblast growth factor-23 IGF-1: Insulin-like growth factor-1 IL-6: Interleukin-6 LC: L-carnitine OPG: Osteoprotegerin OPN: Osteopontin RM: One-repetition maximum RT: Resistance training SOST: Sclerostin SPARC: Secreted protein acidic and rich in cysteine/osteonectin TC: Total carnitine TMA: Trimethylamine TMAO: Trimethylamine N-oxide TNF-: Tumor necrosis factor- References Kanis JA, Cooper C, Rizzoli R, Reginster JY, Scientific Advisory Board of the European Society for C

Liu, Ann

These individual unimolecular multi-agonists activities seemed to harmonize the overall metabolic efficacy, which predominantly results from synergistic glucagon action to increase energy expenditure, GLP-1 action to reduce caloric intake and improve glucose control, and GIP action to potentiate the incretin effect and buffer against the diabetogenic effect of inherent glucagon activity

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Risk of complications: Needles bring risks slight pain, infection risk, injection-site reactions

doi: 10.1155/2013/985815