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More than 60 natural and synthetic cationic peptides are approved in the USA and other major markets for the treatment of cancer and other diseases

The researchers noted several limitations, including a small number of included studies and a focus on weight and BMI without tracking other health markers like blood sugar or cholesterol

Palmieri, L., et al

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Typical criteria include: Documented diagnosis of type 2 diabetes with inadequate glycemic control on metformin or other first-line agents BMI 27 kg/m with weight-related comorbidity or BMI 30 kg/m (for weight management indications) Trial and failure of alternative therapies Absence of contraindications Coverage for weight management indications under commercial plans has expanded but remains inconsistent, with many employers specifically excluding obesity medications from pharmacy benefits