Interactions with drugs: Chloramphenicol can impede on the red blood cell producing properties of B12 Other drugs that decrease or reduce absorption of B12: antibiotics, cobalt irradiation, colchicine, colestipol, H2-blockers, metformin, nicotine, birth control pills, potassium chloride, proton pump inhibitors such as Prevacid, Losec, Aciphex, Pantaloc, and Zidovudine
It affects sterility, potency accuracy, contaminant screening, and the regulatory accountability that comes with a licensed pharmacy supply chain
Reconstitution: A final volume of 3.0 mL produces 33.33 mg/mL
Additionally, with increasing rate or concentration, there is also a risk of anaphylactoid reactions
Plant Cell 16:24482462
Clinical evidence RECONNECT trials: The FDA approval was based on two Phase 3 trials involving over 1,200 premenopausal women with HSDD: Significant increases in Female Sexual Function Index-desire domain scores Reduced distress related to low sexual desire Benefits maintained through 52-week open-label extension Rapid improvement when placebo patients switched to active treatment Earlier research: A 2006 study in premenopausal women with sexual arousal disorder found significantly more women reported moderate or high sexual desire after PT-141 compared to placebo (p=0.0114)