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doi:10.1016/S2213-8587(25)00226-8 Wilding JPH, Batterham RL, Calanna S, et al

Therefore, genetic ablation or pharmacological inhibition of Parp-1 enhances the Sirt1 activity through restoring the NAD + content, providing a protection benefit for various tissues, including the liver, muscle and brown adipose tissue

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& Maradonna, F

[7] [8] This pathway is influenced by the gut microbiome, as intestinal bacteria modify bile acid composition

Novoselova Journal: Immunological Investigations Journal ranking: Q2 Key takeaways: Thymulin, a synthetic thymic peptide, effectively prevents the accumulation of pro-inflammatory cytokines and heat shock protein Hsp70 in inflammation-bearing mice, suggesting potential clinical applications