Wan R, Wang L, Duan Y, Zhu M, Li W, Zhao M, et al
Sharing a 94% structural homology with native human GLP-1, Semaglutide is distinguished by three modifications: 1) amino-acid substitutions at position 8 (alanine to -aminoisobutyric acid or Aib) and position 34 (lysine to arginine), and acylation of the lysine in position 26 with a spacer consisting of two 8-amino-3,6-dioxaoctanoic acid (ADO) moieties, a glutamic acid moiety, and a C-18 fatty di-acid side chain (Lau et al., 2015)
These real-world scenarios happen frequently in clinical practice, even though the evidence base supporting them is thin
Gonadorelin (GnRH) Primary uses: Testosterone support Fertility enhancement Maintaining testicular function during TRT Typical dosing: 100-200mcg, 2-3 times daily (pulsatile dosing) Duration: Ongoing alongside TRT if used for that purpose Administration: Subcutaneous injection Special notes: Requires frequent dosing (mimics natural GnRH pulses) Maintains natural hormone production Used in fertility treatments HCG (Human Chorionic Gonadotropin) Primary uses: Testosterone support Fertility (both male and female) Maintaining testicular size during TRT Weight loss (controversial) Typical dosing: 250-500 IU, 2-3 times per week Duration: Depends on purpose Administration: Subcutaneous or intramuscular injection Special notes: Prescription medication Mimics LH (luteinizing hormone) Well-established safety profile Banned by WADA DSIP (Delta Sleep-Inducing Peptide) Primary uses: Sleep quality Stress reduction Pain management Typical dosing: 100-300mcg before bed Duration: As needed for sleep support Administration: Subcutaneous injection Special notes: Mixed evidence for effectiveness Some users report excellent sleep Others notice minimal effects Very safe with no dependence Vasoactive Intestinal Peptide (VIP) Primary uses: Mold toxicity treatment Immune regulation Inflammatory conditions Typical dosing: 50mcg, 4 times daily Intranasal spray Duration: 4-12 months for mold illness Administration: Intranasal spray (not injectable typically) Special notes: Specialized use for biotoxin illness Prescribed by mold-literate physicians Expensive Requires proper diagnosis How to choose the right injectable peptide With so many options, selection requires strategy
Int Immunopharm (2003) 3:141927
This is sometimes called purging, and it can be confusing
