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inducible, endothelial and neuronal nitric oxide synthase (iNOS eNOS, nNOS respectively), hemeoxygenase-1 (HO-1), intercellular adhesion molecule 1 (ICAM-1), CD40L and CD40L glycoproteins, astrocytes and microglia activation, tumor necrosis factor (TNF), and IL-1 and IL-6 [106109]

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Originally developed by Dr John Myers, a Baltimore physician and Johns Hopkins University graduate, across the mid-twentieth century until his death in 1984, this intravenous nutrient therapy has become a cornerstone of integrative and functional medicine