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Ophthalmology 129 , 438449 (2022)
For many, the result is reduced hunger and a significantly improved metabolic response to food
The pancreas typically produces adequate digestive enzymes in patients without pancreatic insufficiency, and GLP-1 receptor agonists do not directly inhibit enzyme synthesis
59 In contrast, another study demonstrated that adropin levels were increased in serum from patients with Kawasaki disease and even higher in those with coronary artery lesions, and showed positive correlation with inflammatory markers and D-dimer
In addition, GLP-1 can reduce liver cholesterol accumulation by inhibiting SREBP2 and PCSK9, and reduce liver bile acid synthesis by weakening the negative feedback inhibition of bile acid after inhibiting FXR