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Intranasal delivery may produce fewer gastrointestinal side effects due to lower systemic exposure, consistent with findings from intranasal GLP-1 clinical trials

In this study, GLP-1 increased beta cell mass by decreasing the apoptosis of the beta cells

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Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model