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doi: 10.1016/j.freeradbiomed.2015.05.006

Older adults, vegetarians, vegans, and people with digestive problems that can impede nutrient absorption are at a higher risk of vitamin B12 deficiency and need to supplement

Mol Psychiatry 26:54815503

Regular physician follow-ups to assess digestive improvements, adjust protocols as needed, and ensure optimal therapeutic outcomes for gut health

In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig