Diabetic retinopathy : Rapid improvement in blood glucose control, as seen with some GLP-1 receptor agonists, has been associated with early worsening of diabetic retinopathy in people with pre-existing retinal disease
The lack of dose proportionality observed in SL apomorphine exposure appears to be more pronounced in patients with Parkinsons disease compared to healthy subjects, which may be attributed to extrinsic factors, such as SL film contact time under the tongue and dry mouth [27]
In the SURMOUNT-1 study, which established the standard escalation protocol, gastrointestinal side effects occurred primarily during dose escalation periods, not during maintenance phases
The Journal of Clinical Endocrinology & Metabolism , 100 (11), 4048-4058
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It's particularly important if patients are above 70 years of age or have liver and kidney issues