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Surgery is generally reserved for cases with progressive neurological deficits, cauda equina syndrome (a surgical emergency), or persistent symptoms despite 6 to 12 months of conservative treatment

The peptide also activates alternative angiogenic pathways including VEGF-independent routes via Src-caveolin-1-eNOS signaling, providing redundant mechanisms for vascular regeneration

These are the mesenchymal cells clustered at the bottom of each hair follicle, and they essentially control whether that follicle grows hair or goes dormant