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Ongoing trials are comparing outcomes

To validate the observed closed conformation and to study their effects on receptor activation, we engineered disulfide bonds on the wild-type GLP-1R to lock the interactions between the ECD and ECL1/3

They achieve longer circulation times and extraordinary mucus penetration and do not provoke the immune responses that PEGylated carriers typically do 187,188,189

The samples were homogenized, separated by electrophoresis and immunoblotted for c-Met protein and actin

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