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We conducted all analyses on JMP (Version 16.2.0, SAS Institute Inc., Cary, NC)

We saw cleavage products that suggested trypsin or chymotrypsin-like activity with cleavage after basic and hydrophobic residues (Fig

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doi: 10.1186/s12906-015-0859-1, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 22

Pros Cons No long-term safety data yet Gastrointestinal side effects are commonly reported May cause reactions at injection site Regular monitoring of kidney function is needed Anticipated Mounjaro side effects The safety and tolerability profile for tirzepatide is felt to be similar to other related diabetes medicines such as semaglutide and liraglutide