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therefore, prescribers usually restrict use to adults unless compelling justification exists

In particular, Frssing et al

Proinflammatory properties of glutathione peroxidase-4 Notably, the 718C allele of the GPX4 gene was found to be associated with the increased levels of lymphocyte lipoxygenase products implying that the polymorphism can modulate inflammatory processes through the regulation of the biosynthesis of leukotrienes, thromboxanes and prostaglandins