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In people with obesity, 36 weeks of orforglipron (doses ranging from 12 to 45 mg in a phase 2 trial) resulted in a dose-dependent WL up to 14.7% compared to 2.3% with placebo, with concomitant improvement in cardiometabolic risk factors (Table 2) [25]

This is the maximum studied dose

Retatrutide (triple GLP-1R/GIPR/GCGR agonist, Phase 3): Early Phase 2 data showed ~24% weight loss at 48 weeks the highest reported for any GLP-1R-class agent

Ding, L

FuturHealth does not hard-gate the clinical questionnaire behind an email or account

In June, market research company Worldpanel by Numerator published a study looking at how this affects grocery spending among UK users