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This proposed concept mirrors forward genetics, we know the external phenotype is melanoma, therefore doing a high throughput un-biased screen for serum biomarkers will reveal expression changes of biomarkers between healthy controls, disease-free patients, and melanoma patients, which will provide insights into key driver pathways regulating metastasis

Annagr BB, Kerimoglu S, Tazegl A, Gndz , Genoglu BB