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The results of immunostaining and western blot showed that an obvious increased protein expression of 4-HNE was found in peroxynitrite treated SGNs, while it was significantly decreased in peroxynitrite + ebselen group but further increased in peroxynitrite + gpx1 / mice compared with the peroxynitrite-only group (Figures 5B,C)

Additionally, under stress or disease conditions, such as hypoxia, cellular senescence can be induced