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It was originally designed to treat type 2 diabetes but has gained widespread use for weight loss

Active vitamin D3, 1,25-(OH)2D3, protects against macrovasculopathy in a rat model of type 2 diabetes mellitus

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The pharmacokinetic difference is small enough that it wouldn't change efficacy or side-effect profile in a meaningful way

Other controlled clinical trials with different measurable outputs are needed to further evaluate the efficacy of glutathione as a skin-lightening agent

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