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Subsequent STEP trials expanded the use of semaglutide to chronic weight management, revealing that nearly two-thirds of patients experienced a body weight reduction of at least 15%

Some early insomnia studies found modest improvements in sleep efficiency and sleep latency, while others showed limited or inconsistent benefits

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At the same time, elevated tumor GSH can be exploited as a conditional trigger for prodrug activation, nanomedicine-based delivery, or metal-driven cytotoxicity, thereby converting a classical resistance factor into a therapeutically actionable vulnerability