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Towards personalized allele-specific antisense oligonucleotide therapies for toxic gain-of-function neurodegenerative diseases

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Samples were characterized using three independent platforms: ultrahigh-performance liquid chromatography with tandem mass spectrometry (UPLCMS/MS) in the negative-ion mode, UPLCMS/MS in the positive-ion mode and gas chromatographymass spectrometry (GCMS) after sialylation

Inflammation as a central mechanism in Alzheimers disease

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Tirzepatide carries a boxed warning for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2