According to FDA labeling, metformin is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m or in those with acute or chronic metabolic acidosis
These were expected outcomes based on the drugs action on GLP-1 receptors, which delay gastric emptying and impact appetite regulation
PMC 5787624
When you consistently eat ultra-processed foods high in refined sugars and low in fiber, these L-cells become less responsive, and your natural GLP-1 output diminishes over time
Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I
Your body weight plays a crucial role in your overall health