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Choosing Between Semaglutide and Tirzepatide for Post-Surgical Patients Semaglutide activates only the GLP-1 receptor, whereas tirzepatide (a GLP-1/GIP dual agonist) engages both pathways for potentially stronger appetite suppression

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The future of this therapeutic class in IBD management depends on rigorous prospective trials, such as the COMMIT-CD program, to validate endoscopic healing endpoints and establish standardized protocols for monitoring clinical friction points

Modest weight loss of 1 to 2 kg may occur, partly from reduced caloric intake and partly from fluid shifts