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Joseph Pizzorno, author of the "Homocysteine: friend or foe?" I think rather than being a bad molecule in itself, if it is too high it is just an indicator that the b12 and folate are too low

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IGF-1 LR3 retains the ability to bind IGF-1 and insulin receptors but has reduced binding affinity to insulin-like growth factor-binding proteins (IGFBPs)

The science is clear: your cells are fighting a relentless war against oxidative stress, your mitochondria are struggling to produce energy, and your detoxification pathways are overwhelmed

It advises consulting the provider before starting rather than after