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Fasano, a world-renowned gastroenterologist, in order for autoimmunity to be triggered, three factors must be present (this is referred to as the three-legged stool of autoimmunity): [1] A genetic predisposition Intestinal permeability/leaky gut A triggering event or root cause factor Each of these three legs or factors plays its own role in triggering autoimmunity (explained throughout this article)

DEufemiaPCelliMFinocchiaroRPacificoLViozziLZaccagniniMet alAbnormal intestinal permeability in children with autism

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Despite strong preclinical evidence, further dose-response and clinical trials are warranted

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