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First, the basicity and nucleophilicity of amines are substantially reduced by amide formation

At present, several studies have shown that patients with neurodegenerative diseases have some common pathological characteristics in the early stage of the disease: pathological protein aggregation and mitochondrial damage or mitochondrial dysfunction in vulnerable brain regions (Klemmensen et al., 2024

2010;20:S23948

(2024) Progress in understanding oxidative stress, aging, and aging-related diseases

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