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If you are on levothyroxine or other thyroid medications, periodic thyroid panel checks during active weight loss phases are clinically prudent

Adenosine and acetylcholine are formed in the mammalian heart (Burnstock 2017, Lewartowski and Mackiewicz 2015)

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Here is a clear summary of what the Phase 2 data reported

Clinical Trial Evidence and Weight Loss Outcomes A Phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) showed approximately 24% mean body weight reduction at the highest dose (12 mg) over 48 weeks