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A qualified provider then evaluates whether a dose adjustment, timing change, or alternative formulation would improve tolerability

Bossy, B

This does not necessarily mean the medication is not working

But they don't

Statistics shown reflect anonymized self-reported outcomes from 16,000+ U.S

In contrast, in normal non-cancer rectal tissue, metformin significantly altered the secretion of only three IL-17 related cytokines, suggesting that metformin differentially alters the inflammatory secretome of normal rectal tissue, when compared to rectal cancer tissue, which may support its potential utility as a radiosensitiser