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Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018

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Mosharov, E., M.R

Subsequent database studies have cut both ways: some identifying elevated risk, others finding no statistically significant association

This clinical assessment is especially important for safety, dosing, and overall effectiveness

Careful tracking helps avoid late post-meal lows as the tail overlaps with next snacks or activity