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Even when compared with high-dose GLP-1RAs (such as semaglutide 2 mg) and combinations of GLP-1RA with SGLT-2i, 15 mg of tirzepatide was also found to be the most effective in reducing body weight.

If youre noticing debilitating fatigue or weakness, talk to your doctor about switching to a new medication, which may help relieve these side effects