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Unlike existing medications that act on one or two hormone receptors, retatrutide simultaneously targets three: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
Oral semaglutide: first-in-class oral GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus
Its GIPR-biased mechanism offers unique dissociation of incretin pathways, useful for dissecting individual receptor contributions
It slows more than expected
GLP-1 reduces appetite and enhances insulin sensitivity
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