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A RCT ( n = 23, liraglutide between 6 weeks and 6 months post-op) randomised participants to 3.0 mg liraglutide or placebo after laparoscopic sleeve gastrectomy

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(A) Western blot experiments were used to analyze the expression of relevant proteins in MAPK pathway and PI3K/AKT pathway in DPCs and DSCs respectively after treatments of miR-221, miR-221 + IGF-1 and miR-NC + IGF-1

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The effect is not sedation or restrictionit is a genuine reduction in hunger perception driven by hormonal signaling