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Site-directed mutagenesis Mutant forms of mito GCL refractory to the shRNA against GCL ( mito GCLmut) or catalytically inactive mito GCL ( mito GCL (E103A)) were generated using the site-directed mutagenesis QuikChange XL kit (Stratagene, La Jolla, CA, USA), followed by Dpn I digestion

Studies show that vitamin C helps immune cells reach infection sites more quickly and function more effectively once they arrive

Ionotropic Glutamate Receptors Since NMDA receptors mediate the transfer of Na + into cells, there is a possibility that they represent, in addition to glutamate transporters and metabotropic receptors, another mechanism responsible for the cytotoxic swelling activated by increased glutamate concentrations (Winkler et al., 2016)

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[BSO] is also a powerful antioxidant, which goes hand in hand with its anti-inflammatory properties