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Endocrinology 139:41084114 Li G, Hidaka H, Wollheim CB (1992) Inhibition of voltage-gated Ca 2+ channels and insulin secretion in HIT cells by Ca 2+ /calmodulindependent protein kinase inhibitor KN62: comparison with antagonists of calmodulin and L-type Ca 2+ channels

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Thus sertraline multiple dose pharmacokinetics appear to be unaffected by renal impairment [See Use in Specific Populations (8.7)]

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Patients are encouraged to report any suspected side effects to the MHRA through the Yellow Card scheme (yellowcard