doi: 10.1038/nrgastro.2009.35 383 CryanJFDinanTG
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En los estudios de toxicidad para el desarrollo realizados en conejos y monos cynomolgus, se observ un aumento del nmero de casos de interrupcin de la gestacin y un ligero aumento de la incidencia de anomalas fetales con exposiciones clnicamente relevantes
Common adverse effects are predominantly gastrointestinal and include: Nausea (reported in 1544% of patients) Vomiting (524%) Diarrhea (830%) Constipation (1124%) Abdominal pain (520%) These effects are typically most pronounced during initial treatment and dose escalation, often diminishing over several weeks as tolerance develops
Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
Nevertheless, there are no data on whether the effects of the immune-inflammatory processes during acute infection (as indicated by lowered SpO2 and increased body temperature) on the neuropsychiatric symptoms are mediated by activated immune and O&NS (IO&NS) pathways
